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PFKFB4 抗体 (AA 266-296)

Name: PFKFB4 抗体 (AA 266-296)
SKU: ABIN392786
Availability: OutOfStock

This anti-PFKFB4 antibody is a 兔多克隆 antibody detecting PFKFB4 in WB 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 5+ publications.

All lanes : Anti-PFKFB4 Antibody (Center) at 1:1000 dilution Lane 1: Raji, whole cell lysate Lane 2: Molt-4 whole cell lysate Lane 3: NCI- whole cell lysate Lane 4: 293 whole cell lysate Lane 5: U-87 MG whole cell lysate Lysates/proteins at 20 μg per lane. (PFKFB4 抗体 (AA 266-296))

IHC (p)

3 images

(5 references)

产品编号 ABIN392786

发货至: 中国

Quick Overview for PFKFB4 抗体 (AA 266-296) (ABIN392786)

抗原

See all PFKFB4 抗体

PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This PFKFB4 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB04059

抗原表位
7

5

3

2

1

1

1

1

1
AA 266-296

预测反应

Pr

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This PFKFB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the Central region of human PFKFB4.

亚型

IgG
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) antibody
PFKFB4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) antibody
PFKFB4 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1C8 unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 274-303) antibody
PFKFB4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-368) antibody
PFKFB4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibody
PFKFB4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Cow, Pig, Bat, Hamster, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibody
PFKFB4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (N-Term) antibody
PFKFB4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-296) antibody
PFKFB4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-368) antibody (Biotin)
PFKFB4 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4) (AA 266-368) antibody (HRP)
PFKFB4 适用: 人 ELISA 宿主: 兔 Polyclonal HRP

应用备注

WB: 1:1000. IHC-P: 1:100. IHC-P: 1:250

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Ros, Flöter, Kaymak, Da Costa, Houddane, Dubuis, Griffiths, Mitter, Walz, Blake, Behrens, Brindle, Zamboni, Rider, Schulze: "6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells." in: Oncogene, Vol. 36, Issue 23, pp. 3287-3299, (2017) (PubMed).

Gómez, Manzano, Figueras, Viñals, Ventura, Rosa, Bartrons, Navarro-Sabaté: "Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway." in: American journal of physiology. Endocrinology and metabolism, Vol. 303, Issue 6, pp. E695-707, (2012) (PubMed).

Ros, Santos, Moco, Baenke, Kelly, Howell, Zamboni, Schulze: "Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival." in: Cancer discovery, Vol. 2, Issue 4, pp. 328-43, (2012) (PubMed).

Yalcin, Clem, Simmons, Lane, Nelson, Clem, Brock, Siow, Wattenberg, Telang, Chesney: "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases." in: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24223-32, (2009) (PubMed).

Blum, Jacob-Hirsch, Amariglio, Rechavi, Kloog: "Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death." in: Cancer research, Vol. 65, Issue 3, pp. 999-1006, (2005) (PubMed).
抗原

PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

别名

PFKFB4

背景

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

分子量

54040

基因ID

5210

NCBI登录号

NP_004558

UniProt

Q16877