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PFKFB3 抗体 (C-Term)

Name: PFKFB3 抗体 (C-Term)
SKU: ABIN392768
Availability: OutOfStock

This anti-PFKFB3 antibody is a 兔多克隆 antibody detecting PFKFB3 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 7+ publications.

Western blot analysis of lysate from human kidney tissue lysate, using PFKFB3 Antibody (ABIN392768 and ABIN2842213). (PFKFB3 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (PFKFB3 抗体 (C-Term))

IHC (p)

Western blot analysis of anti-PFKFB3 Antibody (C-term) (ABIN392768 and ABIN2842213) in CEM cell line lysates (35 μg/lane). (PFKFB3 抗体 (C-Term))

3 images

(7 references)

产品编号 ABIN392768

发货至: 中国

Datasheet as PDF

Quick Overview for PFKFB3 抗体 (C-Term) (ABIN392768)

抗原

See all PFKFB3 抗体

PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PFKFB3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB04030

Discover our top product PFKFB3 Primary Antibody

抗原表位
15

15

15

10

8

4

2

2

2

2

1

1

1

1
AA 454-484, C-Term

预测反应

Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This PFKFB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-484 amino acids from the C-terminal region of human PFKFB3.

亚型

Ig Fraction
anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 412-520) antibody
PFKFB3 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F3 unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 400-500) antibody
PFKFB3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 1-520) antibody
PFKFB3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 454-484) antibody
PFKFB3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (C-Term) antibody
PFKFB3 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 401-520) antibody
PFKFB3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (pSer467) antibody
PFKFB3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (AA 1-520) antibody
PFKFB3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) (C-Term) antibody
PFKFB3 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) antibody
PFKFB3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Heydasch, Kessler, Warnke, Eschrich, Scholz, Bigl: "Functional diversity of PFKFB3 splice variants in glioblastomas." in: PloS one, Vol. 16, Issue 7, pp. e0241092, (2021) (PubMed).

Lee, Lee, Yun, Jang, Kang, Kim, Choi, Park: "Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species." in: International journal of nanomedicine, Vol. 11, pp. 55-68, (2016) (PubMed).

Reddy, Fernandes, Deshpande, Weisberg, Inguilizian, Abdel-Wahab, Kung, Levine, Griffin, Sattler: "The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity." in: Leukemia, Vol. 26, Issue 3, pp. 481-9, (2012) (PubMed).

Ando, Uehara, Kogure, Asano, Nakajima, Abe, Kawauchi, Tanaka: "Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3." in: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, Vol. 77, Issue 2, pp. 97-105, (2010) (PubMed).

Yamasaki, Hayashi, Okamoto, Osanai, Lee: "Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice." in: Cancer science, Vol. 101, Issue 1, pp. 65-72, (2010) (PubMed).

Clem, Telang, Clem, Yalcin, Meier, Simmons, Rasku, Arumugam, Dean, Eaton, Lane, Trent, Chesney: "Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth." in: Molecular cancer therapeutics, Vol. 7, Issue 1, pp. 110-20, (2008) (PubMed).

Telang, Yalcin, Clem, Bucala, Lane, Eaton, Chesney: "Ras transformation requires metabolic control by 6-phosphofructo-2-kinase." in: Oncogene, Vol. 25, Issue 55, pp. 7225-34, (2006) (PubMed).
抗原

PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

别名

PFKFB3

背景

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

分子量

59609

基因ID

5209

NCBI登录号

NP_001138915, NP_004557

UniProt

Q16875

途径

AMPK Signaling, Regulation of Carbohydrate Metabolic Process