NEK2 抗体 (AA 396-426)
(6 references)Quick Overview for NEK2 抗体 (AA 396-426) (ABIN392650)
抗原
See all NEK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 396-426
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This NEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-426 amino acids from the Central region of human NEK2.
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亚型
- Ig Fraction
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anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 148-397) antibody
NEK2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 331-445) antibodyNEK2 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 2F6 unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 331-445) antibodyNEK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 1-445) antibodyNEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 1-445) antibodyNEK2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 282-295) antibodyNEK2 适用: 人 WB 宿主: 绵羊 Monoclonal unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 331-445) antibodyNEK2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (C-Term) antibodyNEK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 125-393) antibodyNEK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2) (AA 396-426) antibodyNEK2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "MicroRNA-128 promotes apoptosis in lung cancer by directly targeting NIMA-related kinase 2." in: Thoracic cancer, Vol. 8, Issue 4, pp. 304-311, (2018) (PubMed).
: "NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma." in: Oncology reports, Vol. 36, Issue 2, pp. 853-62, (2017) (PubMed).
: "The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival." in: Nucleic acids research, Vol. 42, Issue 5, pp. 3218-27, (2014) (PubMed).
: "Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation." in: The Journal of cell biology, Vol. 188, Issue 1, pp. 83-100, (2010) (PubMed).
: "Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas." in: The Journal of pathology, Vol. 217, Issue 3, pp. 431-41, (2009) (PubMed).
: "Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26431-40, (2007) (PubMed).
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: "MicroRNA-128 promotes apoptosis in lung cancer by directly targeting NIMA-related kinase 2." in: Thoracic cancer, Vol. 8, Issue 4, pp. 304-311, (2018) (PubMed).
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- NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
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别名
- NEK2
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背景
- Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
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分子量
- 51763
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基因ID
- 4751
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NCBI登录号
- NP_001191111, NP_001191112, NP_002488
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UniProt
- P51955
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途径
- M Phase
抗原
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