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PRKG2 抗体 (C-Term)

Name: PRKG2 抗体 (C-Term)
SKU: ABIN392537
Availability: OutOfStock

This anti-PRKG2 antibody is a 兔多克隆 antibody detecting PRKG2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 4+ publications.

All lanes : Anti-cGKII Antibody (C-term) at 1:1000 dilution Lane 1: HUVEC whole cell lysate Lane 2: Caco2 whole cell lysate Lane 3: MCF-7 whole cell lysate Lysates/proteins at 20 μg per lane. (PRKG2 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with cGKII antibody (C-term) (ABIN392537 and ABIN2842089) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (PRKG2 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (PRKG2 抗体 (C-Term))

IHC (p)

3 images

(4 references)

产品编号 ABIN392537

发货至: 中国

Quick Overview for PRKG2 抗体 (C-Term) (ABIN392537)

抗原

See all PRKG2 抗体

PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PRKG2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB01036

抗原表位
11

6

2

2

2

2

2

2

2

1

1

1

1

1

1

1
AA 714-744, C-Term

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This cGKII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 714-744 amino acids from the C-terminal region of human cGKII.

亚型

Ig Fraction
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Internal Region) antibody
PRKG2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Ser363), (Thr359) antibody
PRKG2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) antibody
PRKG2 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Ser126) antibody
PRKG2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (AA 453-728) antibody
PRKG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (AA 1-100) antibody
PRKG2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (N-Term) antibody
PRKG2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (N-Term) antibody
PRKG2 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (C-Term) antibody
PRKG2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (pSer126) antibody
PRKG2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Zhu, Yao, Wu, Qian, Wu, Chen: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).

Yao, Wu, Zhu, Qian, Chen et al.: "Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine ..." in: Oncology letters, Vol. 10, Issue 1, pp. 479-484, (2015) (PubMed).

Jiang, Wu, Wu, Lan, Wang, Qian, Chen: "Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines." in: Oncology letters, Vol. 9, Issue 6, pp. 2781-2786, (2015) (PubMed).

Rangaswami, Marathe, Zhuang, Chen, Yeh, Frangos, Boss, Pilz: "Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14796-808, (2009) (PubMed).
抗原

PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

别名

cGKII

背景

CGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50 % of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.

分子量

87432

基因ID

5593

NCBI登录号

NP_006250

UniProt

Q13237