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STK39 抗体 (AA 346-376)

Name: STK39 抗体 (AA 346-376)
SKU: ABIN392497
Availability: OutOfStock

This anti-STK39 antibody is a 兔多克隆 antibody detecting STK39 in WB 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 4+ publications.

Western blot analysis of lysate from 293 cell line, using SK Antibody (ABIN392497 and ABIN2842067). (STK39 抗体 (AA 346-376))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (STK39 抗体 (AA 346-376))

IHC (p)

Western blot analysis of lysate from HepG2 cell line, using SK Antibody (ABIN392497 and ABIN2842067). (STK39 抗体 (AA 346-376))

Western blot analysis of anti-SK b (ABIN392497 and ABIN2842067) in mouse liver tissue lysate. (STK39 抗体 (AA 346-376))

SK Antibody (ABIN392497 and ABIN2842067) western blot analysis in cell line lysates (35 μg/lane). (STK39 抗体 (AA 346-376))

Western blot analysis of SK (arrow) using rabbit polyclonal SK Antibody (ABIN392497 and ABIN2842067). (STK39 抗体 (AA 346-376))

7 images

(4 references)

产品编号 ABIN392497

发货至: 中国

Quick Overview for STK39 抗体 (AA 346-376) (ABIN392497)

抗原

See all STK39 抗体

STK39 (serine threonine Kinase 39 (STK39))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This STK39 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB03418

Discover our top product STK39 Primary Antibody

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AA 346-376

预测反应

Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This SPAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-376 amino acids from the Central region of human SPAK.

亚型

Ig Fraction
anti-serine threonine Kinase 39 (STK39) antibody
STK39 适用: 人 WB, IHC, IP, IF 宿主: 兔 Monoclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (Internal Region) antibody
Verified STK39 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (Ser325) antibody
STK39 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (Ser311) antibody
STK39 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (AA 63-545) antibody
STK39 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (pSer311) antibody
STK39 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) antibody
STK39 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 4E3 unconjugated

anti-serine threonine Kinase 39 (STK39) (C-Term) antibody
STK39 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (pSer325) antibody
STK39 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-serine threonine Kinase 39 (STK39) (AA 151-200) antibody
STK39 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠, Bat, 猴, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Yang, Cai, Zhou, Chen, Chen, Chen, Wang, Fang, Zhou: "STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy." in: PLoS ONE, Vol. 8, Issue 9, pp. e74614, (2013) (PubMed).

Wang, OConnell, McArdle, Wade, Dorff, Shah, Shi, Pan, Rampersaud, Shen, Kim, Subramanya, Steinle, Parsa, Ober, Welling, Chakravarti, Weder, Cooper, Mitchell, Shuldiner, Chang: "From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 1, pp. 226-31, (2009) (PubMed).

Smith, Smallwood, Altman, Liedtke: "PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 283, Issue 32, pp. 22147-56, (2008) (PubMed).

Liedtke, Wang, Smallwood: "Role for protein phosphatase 2A in the regulation of Calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function." in: The Journal of biological chemistry, Vol. 280, Issue 27, pp. 25491-8, (2005) (PubMed).
抗原

STK39 (serine threonine Kinase 39 (STK39))

别名

SPAK

背景

SPAK is a serine/threonine kinase containing an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain, a nuclear localization signal, a consensus caspase cleavage recognition motif, and a C-terminal region. Northern blot analysis detects ubiquitous expression, most abundantly in brain and pancreas. SPAK can phosphorylate itself and an exogenous substrate in vitro. SPAK immunoprecipitates from transfected mammalian cells in a complex with another serine/threonine kinase that phosphorylates catalytically inactive SPAK. SPAK activates the p38 MAP kinase pathway in cotransfection assays. Full-length SPAK is expressed in the cytoplasm in transfected cells, while a mutant corresponding to caspase-cleaved STK39 localizes predominantly in the nucleus.

分子量

59474

基因ID

27347

NCBI登录号

NP_037365

UniProt

Q9UEW8