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MAP3K9 抗体 (C-Term)

Cited in 3+ publications. This 兔 多克隆 anti-MAP3K9 antibody (Clone RB0983) specifically detects MAP3K9 in WB 和 IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN392422
发货至: 中国
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Quick Overview for MAP3K9 抗体 (C-Term) (ABIN392422)

抗原

See all MAP3K9 抗体
MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

适用

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宿主

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克隆类型

  • 73
多克隆

标记

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This MAP3K9 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB0983
  • 抗原表位

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    AA 1070-1104, C-Term

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This MLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1104 amino acids from the C-terminal region of human MLK1.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Polesskaya, Cunningham, Francis, Luebke, Zhu, Collins, Vasilyeva, Sahler, Desmet, Gelbard, Maggirwar, Walton, Frisina, Dewhurst: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." in: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).

    Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).

    Strath, Georgopoulos, Kellam, Blair: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." in: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).

  • 抗原

    MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

    别名

    MLK1

    背景

    MLK1 is a MLK(MAP3K) type protein kinase. The catalytic domain of mixed-lineage kinases (MLKs) kinases have amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition to thee unusual nature of the kinase catalytic domains, MLK1 and MLK2 contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. MLK1 is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. MLK1 expression has been documented in human epithelial tumor cell lines of colonic, breast and esophageal origin.

    分子量

    121895

    基因ID

    4293

    NCBI登录号

    NP_149132

    UniProt

    P80192
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