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Cullin 5 抗体 (C-Term)

This 兔 多克隆 anti-Cullin 5 antibody (Clone RB17926) specifically detects Cullin 5 in WB, IHC (p) 和 FACS. The antibody is reactive with 人 samples.
产品编号 ABIN391834
发货至: 中国
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Quick Overview for Cullin 5 抗体 (C-Term) (ABIN391834)

抗原

See all Cullin 5 (CUL5) 抗体
Cullin 5 (CUL5)

适用

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宿主

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克隆类型

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多克隆

标记

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This Cullin 5 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

克隆位点

RB17926
  • 抗原表位

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    AA 747-774, C-Term

    预测反应

    Rb

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This CUL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 747-774 amino acids from the C-terminal region of human CUL5.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    Cullin 5 (CUL5)

    别名

    CUL5

    背景

    CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.

    分子量

    90955

    基因ID

    8065

    NCBI登录号

    NP_003469

    UniProt

    Q93034

    途径

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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