DYRK1B 抗体 (C-Term)
Quick Overview for DYRK1B 抗体 (C-Term) (ABIN391774)
抗原
See all DYRK1B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 561-589, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the C-terminal region of human DYRK1B.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells." in: Cancer cell international, Vol. 13, Issue 1, pp. 2, (2013) (PubMed).
: "The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer." in: International journal of oncology, Vol. 40, Issue 4, pp. 1203-9, (2012) (PubMed).
: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, (2009) (PubMed).
: "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells." in: The Journal of biological chemistry, Vol. 281, Issue 50, pp. 38489-97, (2006) (PubMed).
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: "Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells." in: Cancer cell international, Vol. 13, Issue 1, pp. 2, (2013) (PubMed).
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- DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))
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别名
- DYRK1B
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背景
- DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.
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分子量
- 69198
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基因ID
- 9149
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NCBI登录号
- NP_004705, NP_006474, NP_006475
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UniProt
- Q9Y463
抗原
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