STRADA 抗体 (N-Term)
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北京 101111
Quick Overview for STRADA 抗体 (N-Term) (ABIN391217)
抗原
See all STRADA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 12-41, N-Term
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预测反应
- M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This LYK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-41 amino acids from the N-terminal region of human LYK5.
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亚型
- Ig Fraction
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应用备注
- IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:2000. FC: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- STRADA (STE20-Related Kinase Adaptor alpha (STRADA))
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别名
- LYK5
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背景
- LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
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分子量
- 48369
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基因ID
- 92335
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NCBI登录号
- NP_001003786, NP_001003787, NP_001003788, NP_001159441, NP_001159442, NP_699166
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UniProt
- Q7RTN6
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途径
- AMPK Signaling
抗原
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