Deoxyguanosine Kinase 抗体 (C-Term)
Quick Overview for Deoxyguanosine Kinase 抗体 (C-Term) (ABIN391123)
抗原
See all Deoxyguanosine Kinase (DGUOK) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 241-271, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This Deoxyguanosine Kinase (DGUOK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the C-terminal region of human Deoxyguanosine Kinase (DGUOK).
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亚型
- Ig Fraction
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anti-Deoxyguanosine Kinase (DGUOK) (AA 1-89) antibody
DGUOK 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 3E9 unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 40-277) antibodyDGUOK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) antibodyDGUOK 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (C-Term) antibodyDGUOK 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 40-277) antibodyDGUOK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Deoxyguanosine Kinase (DGUOK) (AA 1-30), (N-Term) antibodyDGUOK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB5277 unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- Deoxyguanosine Kinase (DGUOK)
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背景
- Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.
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分子量
- 32056
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基因ID
- 1716
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NCBI登录号
- NP_550438, NP_550440
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UniProt
- Q16854
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途径
- Ribonucleoside Biosynthetic Process
抗原
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