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PDXK 抗体 (N-Term)

This anti-PDXK antibody (ABIN391110) is a Rabbit Polyclonal antibody detecting PDXK in WB. Suitable for Human, Mouse.
产品编号 ABIN391110
发货至: 中国

Quick Overview for PDXK 抗体 (N-Term) (ABIN391110)

抗原

See all PDXK 抗体
PDXK (Pyridoxal Kinase (PDXK))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This PDXK antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB5460
  • 抗原表位

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    AA 1-30, N-Term

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This PDXK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PDXK.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    PDXK (Pyridoxal Kinase (PDXK))

    别名

    PDXK

    背景

    Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.

    分子量

    35102

    基因ID

    8566

    NCBI登录号

    NP_003672

    UniProt

    O00764
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