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RCAN1 抗体 (C-Term)

Name: RCAN1 抗体 (C-Term)
SKU: ABIN390298
Availability: OutOfStock

This anti-RCAN1 antibody is a 兔多克隆 antibody detecting RCAN1 in WB. Suitable for 人. This Primary Antibody has been cited in 8+ publications.

The anti-DSCR1 Pab (ABIN390298 and ABIN2837935) is used in Western blot to detect RCAN1/DSCR1 in endothelial tissue lysate. (RCAN1 抗体 (C-Term))

1 image

(8 references)

产品编号 ABIN390298

发货至: 中国

Quick Overview for RCAN1 抗体 (C-Term) (ABIN390298)

抗原

See all RCAN1 抗体

RCAN1 (Regulator of Calcineurin 1 (RCAN1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This RCAN1 antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

RB4671

Discover our top product RCAN1 Primary Antibody

抗原表位
15

6

6

6

5

5

4

4

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 222-252, C-Term

预测反应

B, Ha, M, Rat, Sh

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This RCAN1/DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1.

亚型

Ig Fraction
anti-Regulator of Calcineurin 1 (RCAN1) (AA 60-245) antibody
RCAN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (Middle Region) antibody
RCAN1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 绵羊, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-100) antibody
RCAN1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B1 unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) antibody
RCAN1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-100) antibody
RCAN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (C-Term) antibody
RCAN1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 1-117) antibody
RCAN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (C-Term) antibody
RCAN1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 41-68), (N-Term) antibody
RCAN1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB36242 unconjugated

anti-Regulator of Calcineurin 1 (RCAN1) (AA 75-104) antibody
RCAN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Wang, Rai, Hur, Smilansky, Chang, Min: "DSCR1 is required for both axonal growth cone extension and steering." in: The Journal of cell biology, Vol. 213, Issue 4, pp. 451-62, (2017) (PubMed).

Lei, Hu, Chen, Yu, Qi, Du, Gu, Lin, Yang: "RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation." in: Molecular immunology, Vol. 77, pp. 26-33, (2017) (PubMed).

Hong, Lee, Chung: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." in: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).

Junkins, MacNeil, Wu, McCormick, Lin: "Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5178-86, (2013) (PubMed).

Stefos, Soppa, Dierssen, Becker: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).

Wang, Zhu, Chang, Min: "DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis." in: The EMBO journal, Vol. 31, Issue 18, pp. 3655-66, (2012) (PubMed).

Hirakawa, Nary, Medh: "Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis." in: Journal of molecular signaling, Vol. 4, pp. 6, (2009) (PubMed).

Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: "Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 195-207, (2009) (PubMed).
抗原

RCAN1 (Regulator of Calcineurin 1 (RCAN1))

别名

DSCR1

背景

DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

分子量

28079

基因ID

1827

NCBI登录号

NP_004405, NP_981962, NP_981963

UniProt

P53805

途径

Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development