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Sclerostin 抗体 (N-Term)

Name: Sclerostin 抗体 (N-Term)
SKU: ABIN2840682
Availability: OutOfStock

Cited in 2+ publications. This anti-Sclerostin antibody is a 兔多克隆 antibody detecting Sclerostin in WB 和 IHC (p). Suitable for 人, 小鼠和大鼠.

Western blot analysis of lysates from mouse liver, mouse lung, rat kidney tissue lysate (from left to right), using SOST Antibody (N-term) (ABIN390193 and ABIN2840682). (Sclerostin 抗体 (N-Term))

Immunohistochemical analysis of paraffin-embedded Human kidney tissue using A performed on the Leica® BOND RXm. (Sclerostin 抗体 (N-Term))

IHC (p)

All lanes : Anti-SOST Antibody (N-term) at 1:2000 dilution Lane 1: mouse lung lysates Lane 2: human liver lysates Lane 3: Hela whole cell lysates Lysates/proteins at 20 μg per lane. (Sclerostin 抗体 (N-Term))

All lanes : Anti-SOST Antibody (N-term) at 1:1000 dilution Lane 1: human kidney lysates Lane 2: human liver lysates Lysates/proteins at 20 μg per lane. (Sclerostin 抗体 (N-Term))

Anti-SOST Antibody (N-term) at 1:2000 dilution + Recombinant human SOST protein lysate Lysates/proteins at 20 ng per lane. (Sclerostin 抗体 (N-Term))

5 images

(2 references)

产品编号 ABIN2840682

发货至: 中国

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Quick Overview for Sclerostin 抗体 (N-Term) (ABIN2840682)

抗原

See all Sclerostin (SOST) 抗体

Sclerostin (SOST)

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Sclerostin antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB12388

抗原表位
15

10

8

7

3

3

2

2

1

1

1

1

1

1

1

1

1

1
AA 12-42, N-Term

预测反应

B

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human SOST.

亚型

IgG
anti-Sclerostin (SOST) (AA 12-42), (N-Term) antibody
SOST 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB12388 unconjugated

anti-Sclerostin (SOST) (AA 121-180) antibody
SOST 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IF (p), ICC, IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 25-213) antibody
SOST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 24-213) antibody
SOST 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 24-213) antibody
SOST 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (N-Term) antibody
SOST 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 25-209) antibody
SOST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (C-Term) antibody
Verified SOST 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 38-87) antibody
SOST 适用: 人, 犬, Pig, 马, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Sclerostin (SOST) (AA 134-163) antibody
SOST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13011 unconjugated

应用备注

WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:2000. IHC-P-Leica: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Zarei, Hulley, Sabokbar, Javaid: "Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips." in: Calcified tissue international, Vol. 100, Issue 6, pp. 609-618, (2018) (PubMed).

Lin, Lin, Chang, Wang, Lai: "Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation." in: Bioelectromagnetics, Vol. 36, Issue 7, pp. 494-505, (2015) (PubMed).
抗原

Sclerostin (SOST)

别名

SOST

背景

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

分子量

24031

基因ID

50964

NCBI登录号

NP_079513

UniProt

Q9BQB4