MLLT10 抗体 (C-Term)
Quick Overview for MLLT10 抗体 (C-Term) (ABIN390125)
抗原
See all MLLT10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 998-1027, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This MLLT10 (AF10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1027 amino acids from the C-terminal region of human MLLT10 (AF10).
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亚型
- Ig Fraction
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anti-Protein AF-10 (MLLT10) (AA 294-323) antibody
MLLT10 适用: 人 WB, IF 宿主: 兔 Polyclonal RB8383 unconjugated
anti-Protein AF-10 (MLLT10) (Internal Region) antibodyMLLT10 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-10 (MLLT10) (AA 695-793) antibodyMLLT10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B9 unconjugated
anti-Protein AF-10 (MLLT10) antibodyMLLT10 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-10 (MLLT10) (Internal Region) antibodyVerified MLLT10 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Protein AF-10 (MLLT10) (Internal Region) antibodyMLLT10 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-10 (MLLT10) (AA 250-500) antibodyMLLT10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-10 (MLLT10) (C-Term) antibodyMLLT10 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- MLLT10 (Protein AF-10 (MLLT10))
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别名
- MLLT10 (AF10)
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背景
- Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10,11)(p12,q23) translocations. In an analysis of two leukemia patients, the in t(10,11)(p12,q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10,11)(p12,q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.
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分子量
- 113320
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基因ID
- 8028
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NCBI登录号
- NP_001182555, NP_001182556, NP_001182557, NP_001182559, NP_004632
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UniProt
- P55197
抗原
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