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EDG4 抗体 (N-Term)

This 兔 多克隆 antibody specifically detects EDG4 in WB 和 IHC (p). It exhibits reactivity toward 人. It has been mentioned in 5+ publications
产品编号 ABIN390085
发货至: 中国
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Quick Overview for EDG4 抗体 (N-Term) (ABIN390085)

抗原

See all EDG4 (LPAR2) 抗体
EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

适用

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宿主

  • 66
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克隆类型

  • 67
多克隆

标记

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This EDG4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB1827
  • 抗原表位

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    AA 3-32, N-Term

    预测反应

    Pr

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This EDG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human EDG4.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Yamauchi, Yamamura, Katase, Itadani, Okada, Kobiki, Nakamura, Yamaguchi, Kuribayashi: "Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device." in: BMC cancer, Vol. 17, Issue 1, pp. 234, (2017) (PubMed).

    Geng, Lan, Singha, Gilchrist, Weinreb, Violette, Weinberg, Saikumar, Venkatachalam: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).

    Bernhart, Kollroser, Rechberger, Reicher, Heinemann, Schratl, Hallström, Wintersperger, Nusshold, DeVaney, Zorn-Pauly, Malli, Graier, Malle, Sattler: "Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture." in: Proteomics, Vol. 10, Issue 1, pp. 141-58, (2010) (PubMed).

    Todorova, Fuentes, Soria, Nadal, Quesada: "Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway." in: Cellular signalling, Vol. 21, Issue 4, pp. 523-8, (2009) (PubMed).

    Horak, Lee, Elkahloun, Boissan, Dumont, Maga, Arnaud-Dabernat, Palmieri, Stetler-Stevenson, Lacombe, Meltzer, Steeg: "Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2." in: Cancer research, Vol. 67, Issue 15, pp. 7238-46, (2007) (PubMed).

  • 抗原

    EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

    别名

    EDG4

    背景

    EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

    分子量

    39084

    基因ID

    9170

    NCBI登录号

    NP_004711

    UniProt

    Q9HBW0
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