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NFkB 抗体 (pSer536)

Name: NFkB 抗体 (pSer536)
SKU: ABIN389601
Availability: OutOfStock

This anti-NFkB antibody is a 兔多克隆 antibody detecting NFkB in WB. Suitable for 人和小鼠. This Primary Antibody has been cited in 2+ publications.

Western blot analysis of lysates from Hela cell line, untreated or treated with TNF-α, 20 ng/mL, using Phospho-NFKBp65 Antibody (upper) or Beta-actin (lower). (NFkB 抗体 (pSer536))

1 image

(2 references)

产品编号 ABIN389601

发货至: 中国

Quick Overview for NFkB 抗体 (pSer536) (ABIN389601)

抗原

See all NFkB 抗体

NFkB (Nuclear Factor kappa B (NFkB))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This NFkB antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

RB5212

Discover our top product NFkB Primary Antibody

抗原表位
5

2

2

2

2

2

2

2

1

1

1
pSer536

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This NFKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NFKB.

亚型

Ig Fraction
anti-Nuclear Factor kappa B (NFkB) (AA 42-367) antibody
NFkB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) (AA 805-892) antibody
NFkB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) (AA 352-439) antibody
NFkB 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) (AA 40-365) antibody
NFkB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) antibody
KD Validated NFkB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody

anti-Nuclear Factor kappa B (NFkB) antibody
NFkB 适用: 人 CP unconjugated

anti-Nuclear Factor kappa B (NFkB) (AA 47-372) antibody
NFkB 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) (pSer536) antibody
NFkB 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) antibody
NFkB 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated

anti-Nuclear Factor kappa B (NFkB) antibody
NFkB 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated

应用备注

WB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Li, Lu, Yu, Han, Wang, Mao, Shen, Wang, Tang, Li, Song: "miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation." in: Chemico-biological interactions, Vol. 277, pp. 33-42, (2017) (PubMed).

Wang, Cai, Shao, Siddiqui, Palanisamy, Li, Ren, Ayala, Ittmann: "Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4." in: Cancer research, Vol. 71, Issue 4, pp. 1325-33, (2011) (PubMed).
抗原

NFkB (Nuclear Factor kappa B (NFkB))

别名

NFKB

背景

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

分子量

60219

基因ID

5970

NCBI登录号

NP_001138610, NP_001230913, NP_068810

UniProt

Q04206

途径

Ubiquitin Proteasome Pathway, S100 Proteins