PAPSS1 抗体 (C-Term)
(1 reference)Quick Overview for PAPSS1 抗体 (C-Term) (ABIN389138)
抗原
See all PAPSS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 592-624, C-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.
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亚型
- Ig Fraction
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anti-3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1) (AA 144-252) antibody
PAPSS1 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 1F4 unconjugated
anti-3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1) antibodyPAPSS1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1) antibodyPAPSS1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1) (AA 1-30), (N-Term) antibodyPAPSS1 适用: 人 WB 宿主: 兔 Polyclonal RB5122 unconjugated
anti-3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1) (AA 144-252) antibodyPAPSS1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1) (AA 190-260) antibodyPAPSS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2." in: Endocrinology, Vol. 150, Issue 5, pp. 2055-63, (2009) (PubMed).
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: "Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2." in: Endocrinology, Vol. 150, Issue 5, pp. 2055-63, (2009) (PubMed).
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- PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))
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别名
- PAPSS1
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背景
- Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98 % identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.
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分子量
- 70833
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基因ID
- 9061
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NCBI登录号
- NP_005434
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UniProt
- O43252
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途径
- Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process
抗原
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