ACSL4 抗体 (AA 236-267)
(11 references)-
- 抗原 See all ACSL4 抗体
- ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))
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抗原表位
- AA 236-267
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ACSL4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This ACSL4 (FACL4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-267 amino acids from the Central region of human ACSL4 (FACL4).
- 克隆位点
- RB04697
- 亚型
- Ig Fraction
- Top Product
- Discover our top product ACSL4 Primary Antibody
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anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (AA 1-280) antibody
ACSL4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (C-Term) antibodyACSL4 适用: 人 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) antibodyACSL4 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (C-Term) antibodyVerified ACSL4 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (AA 457-670) antibodyACSL4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) antibodyACSL4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (AA 244-274) antibodyACSL4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (N-Term) antibodyACSL4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (N-Term) antibodyACSL4 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, Pig, 豚鼠, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) (AA 236-267) antibodyACSL4 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. IHC-P: 1:25
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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: "Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance." in: Experimental cell research, Vol. 359, Issue 1, pp. 86-93, (2017) (PubMed).
: "Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease." in: The EMBO journal, Vol. 36, Issue 22, pp. 3356-3371, (2017) (PubMed).
: "Highly potent intracellular membrane-associated Aβ seeds." in: Scientific reports, Vol. 6, pp. 28125, (2016) (PubMed).
: "Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria-Associated Membrane and Detergent Resistant Membrane Fractions from Transfected Cells and from Human Cytomegalovirus-Infected ..." in: Current protocols in cell biology, Vol. 68, pp. 3.27.1-33, (2016) (PubMed).
: "Human cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of Bax at endoplasmic reticulum-mitochondrion contacts." in: Journal of virology, Vol. 87, Issue 10, pp. 5657-68, (2013) (PubMed).
: "Quantitative proteomic analyses of human cytomegalovirus-induced restructuring of endoplasmic reticulum-mitochondrial contacts at late times of infection." in: Molecular & cellular proteomics : MCP, Vol. 10, Issue 10, pp. M111.009936, (2011) (PubMed).
: "Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 35, pp. 14590-5, (2011) (PubMed).
: "The human cytomegalovirus protein UL37 exon 1 associates with internal lipid rafts." in: Journal of virology, Vol. 85, Issue 5, pp. 2100-11, (2011) (PubMed).
: "Intellectual disability, midface hypoplasia, facial hypotonia, and Alport syndrome are associated with a deletion in Xq22.3." in: American journal of medical genetics. Part A, Vol. 152A, Issue 3, pp. 713-7, (2010) (PubMed).
: "Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria." in: The American journal of pathology, Vol. 175, Issue 5, pp. 1810-6, (2009) (PubMed).
: "PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis." in: The EMBO journal, Vol. 24, Issue 4, pp. 717-29, (2005) (PubMed).
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: "Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance." in: Experimental cell research, Vol. 359, Issue 1, pp. 86-93, (2017) (PubMed).
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- 抗原
- ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))
- 别名
- ACSL4 (FACL4) (ACSL4 产品)
- 别名
- acsl4 antibody, zgc:66186 antibody, ACSL4 antibody, ACS4 antibody, FACL4 antibody, LACS4 antibody, MRX63 antibody, MRX68 antibody, 9430020A05Rik antibody, AU018108 antibody, Facl4 antibody, Lacs4 antibody, Acs4 antibody, acs4 antibody, acsl3 antibody, facl4 antibody, lacs4 antibody, mrx63 antibody, mrx68 antibody, T32A16.20 antibody, T32A16_20 antibody, long-chain acyl-CoA synthetase 4 antibody, acyl-CoA synthetase long chain family member 4a antibody, acyl-CoA synthetase long-chain family member 4 antibody, acyl-CoA synthetase long chain family member 4 antibody, AcsL4 antibody, acyl-CoA synthetase long chain family member 3 antibody, Long-chain-fatty-acid--CoA ligase 4 antibody, acyl-CoA synthetase long-chain family member 4 S homeolog antibody, AMP-dependent synthetase and ligase family protein antibody, acsl4a antibody, ACSL4 antibody, acsL4 antibody, acsl3 antibody, acsl4 antibody, Acsl4 antibody, acsl4.S antibody, LACS4 antibody
- 背景
- Long chain acyl-CoA synthetase (LACS), or long chain fatty acid-CoA ligase (FACL), converts free long chain fatty acids into fatty acyl-CoA esters, key intermediates in the synthesis of complex lipids. The FACL4 gene encodes a form of LACS and is expressed in several tissues, including brain. FACL4 cDNA from brain encodes a gene product that shows preference for arachidonic acid as a substrate when expressed in mammalian cells.1 The sequence of the predicted 670-amino acid human protein is 97 % identical to that of rat ACS4. FACL4 is highly expressed in adult human brain, especially in the cerebellum and hippocampus, similar to the mouse.2 A strong cytoplasmic staining was found in the Purkinje and granular cells of the cerebellum and the pyramidal layer of hippocampus, indicating that FACL4 is specifically expressed in neurons and not in glial cells. Two patients with Alport syndrome, elliptocytosis, and mental retardation carried a large deletion of the COL4A5 region that included FACL4.3 The absence of FACL4 might play a role in the development of mental retardation or other signs associated with Alport syndrome. Two point mutations, 1 missense and 1 splice site change, were reported in the FACL4 gene in 2 families with nonspecific mental retardation.2 Analysis of enzymatic activity in lymphoblastoid cell lines of affected individuals revealed low levels compared with normal cells, indicating that both mutations are null mutations.
- 分子量
- 79188
- 基因ID
- 2182
- NCBI登录号
- NP_004449, NP_075266
- UniProt
- O60488
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