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CBX4 抗体 (C-Term)

CBX4 适用: 人 WB 宿主: 兔 Polyclonal RB2934 unconjugated
产品编号 ABIN389087
发货至: 中国
  • 抗原 See all CBX4 抗体
    CBX4 (Chromobox Homolog 4 (CBX4))
    抗原表位
    • 15
    • 13
    • 10
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 410-437, C-Term
    适用
    • 65
    • 32
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 63
    • 2
    克隆类型
    • 64
    • 1
    多克隆
    标记
    • 23
    • 7
    • 7
    • 7
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBX4 antibody is un-conjugated
    应用范围
    • 59
    • 41
    • 20
    • 14
    • 13
    • 13
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This CBX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-437 amino acids from the C-terminal region of human CBX4.
    克隆位点
    RB2934
    亚型
    Ig Fraction
    Top Product
    Discover our top product CBX4 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • Vincenz, Kerppola: "Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 43, pp. 16572-7, (2008) (PubMed).

    Jones, Fusi, Higham, Abdel-Hafiz, Horwitz, Lam, Brosens: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).

  • 抗原
    CBX4 (Chromobox Homolog 4 (CBX4))
    别名
    CBX4 (CBX4 产品)
    别名
    MPc2 antibody, PC2 antibody, NBP16 antibody, XPolycomb antibody, cbx4-a antibody, im:6911625 antibody, zgc:158588 antibody, chromobox 4 antibody, chromobox 4 S homeolog antibody, chromobox homolog 4 antibody, chromobox homolog 4 (Pc class homolog, Drosophila) antibody, CBX4 antibody, Cbx4 antibody, cbx4.S antibody, cbx4 antibody
    背景
    Chromobox homolog 4 (CBX4 or Pc2) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system that is responsible for the inheritance of gene activity by progeny cells. CBX4 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain. It was reported that Pc2 is involved in sumoylation process by recruiting SUMO E1 and E2, and Pc2 is actually SUMO E3 during sumoylation events. CBX4 expression is ubiquitous.
    分子量
    61368
    基因ID
    8535
    NCBI登录号
    NP_003646
    UniProt
    O00257
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