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AGL 抗体 (C-Term)

Name: AGL 抗体 (C-Term)
SKU: ABIN389030
Availability: OutOfStock

This anti-AGL antibody is a 兔多克隆 antibody detecting AGL in WB 和 IF. Suitable for 人. This Primary Antibody has been cited in 6+ publications.

Anti-AGL Antibody (C-term) at 1:8000 dilution + human skeletal muscle lysate Lysates/proteins at 20 μg per lane. (AGL 抗体 (C-Term))

Expression of myc-GS causes wild type but not the ACBD mutant of AGL to aggregate around the S-stain-positive inclusions. (AGL 抗体 (C-Term))

Western blot using anti-AGL (C-term) antibody ((ABIN6243594 and ABIN6578916)) at 1:1000 dilution. (AGL 抗体 (C-Term))

Confocal immunofluorescent analysis of AGL Antibody (C-term) (ABIN389030 and ABIN2839247) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (AGL 抗体 (C-Term))

4 images

(6 references)

产品编号 ABIN389030

发货至: 中国

Quick Overview for AGL 抗体 (C-Term) (ABIN389030)

抗原

See all AGL 抗体

AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))

适用

人

宿主

兔

克隆类型

多克隆

标记

This AGL antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

RB4978

抗原表位
7

7

4

2

2

2

1

1

1

1

1
AA 1479-1510, C-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This AGL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1479-1510 amino acids from the C-terminal region of human AGL.

亚型

Ig Fraction
anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (AA 357-387) antibody
AGL 适用: 人 WB, IF 宿主: 兔 Polyclonal RB4976 unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (N-Term) antibody
AGL 适用: 人 WB, IF 宿主: 兔 Polyclonal RB5106 unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (AA 1-1532) antibody
AGL 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) antibody
AGL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (AA 1217-1378) antibody
AGL 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (AA 1233-1532) antibody
AGL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) antibody
AGL 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) antibody
KD Validated AGL 适用: 人, 小鼠, 大鼠 WB, IF, IHC, ICC, FACS 宿主: 兔 Monoclonal unconjugated Recombinant Antibody

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (AA 1487-1516), (C-Term) antibody
AGL 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated

anti-Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL) (AA 1217-1378) antibody (HRP)
AGL 适用: 人 ELISA 宿主: 兔 Polyclonal HRP

应用备注

IF: 1:10~50. IF: 1:10~50. WB: 1:1000. WB: 1:8000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Guin, Ru, Agarwal, Ritterson Lew, Owens, Comi, Theodorescu: "Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, (2015) (PubMed).

Liu, Zeng, Ma, Baba, Zheng, Liu, Wang: "Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase." in: Molecular neurobiology, Vol. 49, Issue 2, pp. 645-57, (2014) (PubMed).

Zhu, Shen, Zhu, Coorey, Nguyen, Barthelmes, Gillies: "Anti-retinal antibodies in patients with macular telangiectasia type 2." in: Investigative ophthalmology & visual science, Vol. 54, Issue 8, pp. 5675-83, (2013) (PubMed).

DePaoli-Roach, Tagliabracci, Segvich, Meyer, Irimia, Roach: "Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25372-81, (2010) (PubMed).

Parker, Kong, Walsh, Salajegheh, Moghadaszadeh, Amato, Nazareno, Lin, Krastins, Sarracino, Beggs, Pinkus, Greenberg: "Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis." in: Muscle & nerve, Vol. 39, Issue 6, pp. 739-53, (2009) (PubMed).

Cheng, Zhang, Gentry, Worby, Dixon, Saltiel: "A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease." in: Genes & development, Vol. 21, Issue 19, pp. 2399-409, (2007) (PubMed).
抗原

AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))

别名

AGL

背景

AGL is a glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in the AGL gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing.

分子量

174764

基因ID

178

NCBI登录号

NP_000019, NP_000633, NP_000634, NP_000635, NP_000636, NP_000637

UniProt

P35573

途径

Cellular Glucan Metabolic Process