USP33 抗体 (C-Term)
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Quick Overview for USP33 抗体 (C-Term) (ABIN388945)
抗原
See all USP33 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 799-829, C-Term
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预测反应
- B
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This VDU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 799-829 amino acids from the C-terminal region of human VDU1.
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亚型
- Ig Fraction
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anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 327-426) antibody
USP33 适用: 人 ELISA, WB, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 290-400) antibodyUSP33 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) antibodyUSP33 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 251-550) antibodyUSP33 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 327-427) antibodyUSP33 适用: 人 ELISA, WB, IHC, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (Internal Region) antibodyUSP33 适用: 人, Cow, 犬, 兔, 马, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 1-911) antibodyUSP33 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 799-829) antibodyUSP33 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- USP33 (Ubiquitin Specific Peptidase 33 (USP33))
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别名
- VDU1
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背景
- Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3?-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6
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分子量
- 106727
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基因ID
- 23032
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NCBI登录号
- NP_055832, NP_963918, NP_963920
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UniProt
- Q8TEY7
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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