我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

USP2 抗体 (C-Term)

Name: USP2 抗体 (C-Term)
SKU: ABIN388879
Availability: OutOfStock

This anti-USP2 antibody is a 兔多克隆 antibody detecting USP2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 12+ publications.

Anti-USP2 Antibody at 1:2000 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane. (USP2 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (USP2 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human testis tissue reacted with USP2 antibody (C-term ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (USP2 抗体 (C-Term))

IHC (p)

4 images

(12 references)

产品编号 ABIN388879

发货至: 中国

Quick Overview for USP2 抗体 (C-Term) (ABIN388879)

抗原

See all USP2 抗体

USP2 (Ubiquitin Specific Peptidase 2 (USP2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This USP2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB4417

抗原表位
9

9

7

7

6

5

4

3

2

2

1

1

1

1

1

1

1

1
AA 508-538, C-Term

预测反应

B, M, Rat

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-538 amino acids from the C-terminal region of human USP2.

亚型

Ig Fraction
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 71-101), (N-Term) antibody
USP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4202 unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 200-430), (C-Term) antibody
USP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) antibody
USP2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibody
USP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 9-265) antibody
USP2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-258) antibody
USP2 适用: 人, Green Monkey WB 宿主: 小鼠 Monoclonal 1738CT331-50-87 unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 245-275) antibody
USP2 适用: 人宿主: 兔 Polyclonal RB4416 unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 371-420) antibody
USP2 适用: 人, 犬, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibody
USP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 71-120) antibody
USP2 适用: 人, 大鼠, 犬, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:2000. IHC-P: 1:50~100. IHC-P: 1:50~100. IHC-P: 1:100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid freeze-thaw cycles.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

有效期

6 months
Kitamura, Ishino, Shimamoto, Okabe, Miyamoto, Takahashi, Miyoshi: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." in: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).

Ren, Zhao, Liu, Yuan, Cheng, Zuo, Qian, Liu, Guo, Zhang, Wang, Qian, Li, Ge, Dai, Xiong, Zheng: "Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus." in: PLoS pathogens, Vol. 12, Issue 7, pp. e1005764, (2017) (PubMed).

Davis, Pragani, Fox, Shen, Parmar, Gaudiano, Liu, Tanega, McGee, Hall, McKnight, Shinn, Nelson, Chattopadhyay, DAndrea, Auld, DeLucas, Li, Boxer, Simeonov: "Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24628-24640, (2017) (PubMed).

Boustani, Khoshnood, Nikpasand, Taleshi, Ahmadi, Yahaghi, Goudarzi: "Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas." in: Journal of the neurological sciences, Vol. 363, pp. 249-52, (2016) (PubMed).

Zhang, Zhao, Zhang, Zhao, Gao: "Ubiquitin-specific protease 2b negatively regulates IFN-? production and antiviral activity by targeting TANK-binding kinase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 5, pp. 2230-7, (2014) (PubMed).

Tong, Buelow, Guha, Rausch, Yin: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).

Bedard, Yang, Gregory, Cyr, Suzuki, Yu, Chian, Hermo, OFlaherty, Smith, Clarke, Wing: "Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility." in: Biology of reproduction, Vol. 85, Issue 3, pp. 594-604, (2011) (PubMed).

Oberfeld, Ruffieux-Daidié, Vitagliano, Pos, Verrey, Staub: "Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2." in: American journal of physiology. Renal physiology, Vol. 301, Issue 1, pp. F189-96, (2011) (PubMed).

Allende-Vega, Sparks, Lane, Saville: "MdmX is a substrate for the deubiquitinating enzyme USP2a." in: Oncogene, Vol. 29, Issue 3, pp. 432-41, (2010) (PubMed).

Shan, Zhao, Gu: "Suppression of cancer cell growth by promoting cyclin D1 degradation." in: Molecular cell, Vol. 36, Issue 3, pp. 469-76, (2009) (PubMed).

Zweitzig, Shcherbik, Haines: "Retraction for D. R. Zweitzig, N. Shcherbik, and D. S. Haines: AAA ATPase P97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive P53 turnover." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 5029, (2008) (PubMed).

Stevenson, Sparks, Allende-Vega, Xirodimas, Lane, Saville: "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2." in: The EMBO journal, Vol. 26, Issue 4, pp. 976-86, (2007) (PubMed).
抗原

USP2 (Ubiquitin Specific Peptidase 2 (USP2))

别名

USP2

背景

USP2, an ubiquitin-specific protease, is selectively up regulated in bone by the osteotropic agents PTH, PTHrP and PGE2 and possibly via the PKA/cAMP pathway. It is also thought to play a role in the recycling of ubiquitin by hydrolysis of branched poly-ubiquitin from linear poly-ubiquitin chains, production of free ubiquitin from linear poly-ubiquitin chains and from certain ribosomal ubiquitin fusion proteins.

分子量

68072

基因ID

9099

NCBI登录号

NP_001230688, NP_004196, NP_741994

UniProt

O75604