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Osteocalcin 抗体 (N-Term)

BGLAP 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB04507-04508 unconjugated
产品编号 ABIN388727
发货至: 中国
  • 抗原 See all Osteocalcin (BGLAP) 抗体
    Osteocalcin (BGLAP)
    抗原表位
    • 15
    • 10
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-32, N-Term
    适用
    • 100
    • 43
    • 21
    • 20
    • 19
    • 15
    • 15
    • 10
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    宿主
    • 91
    • 32
    • 2
    • 2
    • 1
    克隆类型
    • 95
    • 33
    多克隆
    标记
    • 74
    • 13
    • 11
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Osteocalcin antibody is un-conjugated
    应用范围
    • 96
    • 71
    • 50
    • 15
    • 15
    • 14
    • 14
    • 9
    • 9
    • 8
    • 8
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This Osteocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin.
    克隆位点
    RB04507-04508
    亚型
    Ig Fraction
    Top Product
    Discover our top product BGLAP Primary Antibody
  • 应用备注
    WB: 1:2000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    Osteocalcin (BGLAP)
    别名
    Osteocalcin (BGLAP 产品)
    别名
    BGP antibody, OC antibody, OCN antibody, Bglap1 antibody, Bglap2 antibody, OG1 antibody, mOC-A antibody, Bgp antibody, Bgpr antibody, Bgpra antibody, bgp antibody, LOC792433 antibody, ocn antibody, GLA antibody, BGLAP antibody, PMF1 antibody, bone gamma-carboxyglutamate protein antibody, bone gamma carboxyglutamate protein antibody, bone gamma-carboxyglutamate protein S homeolog antibody, bone gamma-carboxyglutamate (gla) protein antibody, osteocalcin antibody, polyamine-modulated factor 1 antibody, BGLAP antibody, Bglap antibody, bglap.S antibody, bglap antibody, ocn antibody, LOC100529177 antibody, LOC100146589 antibody
    背景
    Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2 % of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.
    分子量
    10963
    基因ID
    632
    NCBI登录号
    NP_954642
    UniProt
    P02818
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