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Osteocalcin 抗体 (N-Term)

Name: Osteocalcin 抗体 (N-Term)
SKU: ABIN388727
Availability: OutOfStock

This anti-Osteocalcin antibody is a 兔多克隆 antibody detecting Osteocalcin in WB 和 IHC (p). Suitable for 人.

Anti-OSTC Antibody (C16) at 1:2000 dilution + MG-63 whole cell lysate Lysates/proteins at 20 μg per lane. (Osteocalcin 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Osteocalcin 抗体 (N-Term))

IHC (p)

2 images

产品编号 ABIN388727

发货至: 中国

Quick Overview for Osteocalcin 抗体 (N-Term) (ABIN388727)

抗原

See all Osteocalcin (BGLAP) 抗体

Osteocalcin (BGLAP)

适用

人

宿主

兔

克隆类型

多克隆

标记

This Osteocalcin antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB04507-04508

Discover our top product BGLAP Primary Antibody

抗原表位
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AA 2-32, N-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Osteocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin.

亚型

Ig Fraction
anti-Osteocalcin (BGLAP) (AA 14-95) antibody
BGLAP 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 21-100) antibody
BGLAP 适用: 人, 大鼠, 小鼠, 犬 WB, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 52-100) antibody
BGLAP 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D4 unconjugated

anti-Osteocalcin (BGLAP) (AA 1-100) antibody
BGLAP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 21-80) antibody
BGLAP 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 52-100) antibody
BGLAP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 2-32) antibody
BGLAP 适用: 人 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 21-99) antibody
BGLAP 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Osteocalcin (BGLAP) (AA 21-99) antibody
BGLAP 适用: 人 IHC, WB 宿主: 小鼠 Monoclonal J10 unconjugated

anti-Osteocalcin (BGLAP) (AA 11-98) antibody
BGLAP 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:2000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
抗原

Osteocalcin (BGLAP)

别名

Osteocalcin

背景

Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2 % of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.

分子量

10963

基因ID

632

NCBI登录号

NP_954642

UniProt

P02818