Osteocalcin 抗体 (N-Term)
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- 抗原 See all Osteocalcin (BGLAP) 抗体
- Osteocalcin (BGLAP)
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抗原表位
- AA 2-32, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Osteocalcin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This Osteocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin.
- 克隆位点
- RB04507-04508
- 亚型
- Ig Fraction
- Top Product
- Discover our top product BGLAP Primary Antibody
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anti-Osteocalcin (BGLAP) (AA 14-95) antibody
BGLAP 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-100) antibodyBGLAP 适用: 人, 大鼠, 小鼠, 犬 ELISA, WB, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 52-100) antibodyBGLAP 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 2D4 unconjugated
anti-Osteocalcin (BGLAP) (AA 1-100) antibodyBGLAP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-80) antibodyBGLAP 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC (p), IHC (fro), FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 52-100) antibodyBGLAP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 2-32) antibodyBGLAP 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-99) antibodyBGLAP 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteocalcin (BGLAP) (AA 21-99) antibodyBGLAP 适用: 人 IHC, WB, IP, ICC 宿主: 小鼠 Monoclonal J10 unconjugated
anti-Osteocalcin (BGLAP) (AA 21-97) antibodyBGLAP 适用: 小鸡 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:2000. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- Osteocalcin (BGLAP)
- 别名
- Osteocalcin (BGLAP 产品)
- 背景
- Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2 % of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.
- 分子量
- 10963
- 基因ID
- 632
- NCBI登录号
- NP_954642
- UniProt
- P02818
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