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Osteocalcin 抗体 (N-Term)

This anti-Osteocalcin antibody is a 兔 多克隆 antibody detecting Osteocalcin in WB 和 IHC (p). Suitable for 人.
产品编号 ABIN388727
发货至: 中国

Quick Overview for Osteocalcin 抗体 (N-Term) (ABIN388727)

抗原

See all Osteocalcin (BGLAP) 抗体
Osteocalcin (BGLAP)

适用

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宿主

  • 84
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克隆类型

  • 89
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多克隆

标记

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This Osteocalcin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB04507-04508
  • 抗原表位

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    AA 2-32, N-Term

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This Osteocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:2000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    Osteocalcin (BGLAP)

    别名

    Osteocalcin

    背景

    Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2 % of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.

    分子量

    10963

    基因ID

    632

    NCBI登录号

    NP_954642

    UniProt

    P02818
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