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SUMO2 抗体 (C-Term)

This anti-SUMO2 antibody is a 兔 多克隆 antibody detecting SUMO2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN388085
发货至: 中国

Quick Overview for SUMO2 抗体 (C-Term) (ABIN388085)

抗原

See all SUMO2 抗体
SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

适用

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宿主

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克隆类型

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多克隆

标记

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This SUMO2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB2761
  • 抗原表位

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    AA 63-93, C-Term

    预测反应

    X, Zf, B, C, Ha, Pr, M, Pig, Rat

    纯化方法

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    免疫原

    This SUMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 amino acids from the C-terminal region of human SUMO2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Ito, Nakamura, Mori, Miki, Tanji, Wakabayashi: "Novel eosinophilic neuronal cytoplasmic inclusions in the external cuneate nucleus of humans." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 36, Issue 5, pp. 441-447, (2017) (PubMed).

    Mori, Tanji, Odagiri, Hattori, Hoshikawa, Kono, Yasui, Yokoi, Hasegawa, Kamitani, Yoshida, Wakabayashi: "Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease." in: Pathology international, Vol. 62, Issue 6, pp. 407-11, (2012) (PubMed).

    Mori, Miki, Tanji, Ogura, Yagihashi, Jensen, Wakabayashi: "Incipient intranuclear inclusion body disease in a 78-year-old woman." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 31, Issue 2, pp. 188-93, (2011) (PubMed).

    Janer, Werner, Takahashi-Fujigasaki, Daret, Fujigasaki, Takada, Duyckaerts, Brice, Dejean, Sittler: "SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7." in: Human molecular genetics, Vol. 19, Issue 1, pp. 181-95, (2009) (PubMed).

    Zhang, Sarge: "Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies." in: The Journal of cell biology, Vol. 182, Issue 1, pp. 35-9, (2008) (PubMed).

  • 抗原

    SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

    别名

    SUMO2

    背景

    SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.

    分子量

    10871

    基因ID

    6613

    NCBI登录号

    NP_001005849, NP_008868

    UniProt

    P61956

    途径

    Methionine Biosynthetic Process
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