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LSD1 抗体 (C-Term)

Name: LSD1 抗体 (C-Term)
SKU: ABIN388023
Availability: OutOfStock

This anti-LSD1 antibody is a 兔多克隆 antibody detecting LSD1 in WB, IF 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 2+ publications.

Western blot analysis of AOF2 (arrow) using LSD1 Antibody (C-term) (ABIN388023 and ABIN2845465). (LSD1 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (LSD1 抗体 (C-Term))

IHC (p)

Fluorescent confocal image of Hela cell stained with hLSD1- (ABIN388023 and ABIN2845465). (LSD1 抗体 (C-Term))

4 images

(2 references)

产品编号 ABIN388023

发货至: 中国

Quick Overview for LSD1 抗体 (C-Term) (ABIN388023)

抗原

See all LSD1 (KDM1A) 抗体

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

适用

人

宿主

兔

克隆类型

多克隆

标记

This LSD1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB7583

Discover our top product KDM1A Primary Antibody

抗原表位
15

8

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3

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 819-852, C-Term

预测反应

M

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This LSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 819-852 amino acids from the C-terminal region of human LSD1.

亚型

Ig Fraction
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibody
KDM1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibody
KO Validated KDM1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibody
KDM1A 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9D2 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 709-876) antibody
KDM1A 适用: 人, 小鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 1H2F8 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibody
KDM1A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142) antibody
KDM1A 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody
KDM1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 1G7 unconjugated Recombinant Antibody

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody
KDM1A 适用: 人 WB, IP, ICC 宿主: 小鼠 Monoclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Huang, Li, Song, Li, Li, Zhang, Han, Zhang, Miao, Du, Wang: "Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/?-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]." in: PLoS ONE, Vol. 8, Issue 7, pp. e70077, (2013) (PubMed).

Nishikawa, Toyota, Suzuki, Honma, Fujikane, Ohmura, Nishidate, Ohe-Toyota, Maruyama, Sonoda, Sasaki, Urano, Imai, Hirata, Tokino: "Gene amplification and overexpression of PRDM14 in breast cancers." in: Cancer research, Vol. 67, Issue 20, pp. 9649-57, (2007) (PubMed).
抗原

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

别名

LSD1

背景

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

分子量

92903

基因ID

23028

NCBI登录号

NP_001009999, NP_055828

UniProt

O60341

途径

Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect