PRDM14 抗体 (N-Term)
Quick Overview for PRDM14 抗体 (N-Term) (ABIN388018)
抗原
See all PRDM14 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
 - AA 1-30, N-Term
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纯化方法
 - This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
 - This PRDM14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PRDM14.
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亚型
 - Ig Fraction
 
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应用备注
 - IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100
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限制
 - 仅限研究用
 
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状态
 - Liquid
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缓冲液
 - Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
 - 6 months
 
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                                            : "Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile."    in: The EMBO journal, Vol. 34, Issue 8, pp. 1009-24, (2015)         (PubMed).        
: "PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells." in: Biochemical and biophysical research communications, Vol. 367, Issue 4, pp. 899-905, (2008) (PubMed).
: "PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4786-94, (2007) (PubMed).
: "Gene amplification and overexpression of PRDM14 in breast cancers." in: Cancer research, Vol. 67, Issue 20, pp. 9649-57, (2007) (PubMed).
 
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                                            : "Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile."    in: The EMBO journal, Vol. 34, Issue 8, pp. 1009-24, (2015)         (PubMed).        
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- PRDM14 (PR Domain Containing 14 (PRDM14))
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别名
 - PRDM14 (PFM11)
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背景
 - Similar to acetylation and phosphorylation, histone methylation at the N terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET domain containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET domain family, and another 17 make up the PR domain family that is related to the SET domain family. PRDM14 is part of a family of PR domain genes that are involved in tumorigenesis. It may function as a transcription factor.
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分子量
 - 64062
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基因ID
 - 63978
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NCBI登录号
 - NP_078780
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UniProt
 - Q9GZV8
 
抗原
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