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PRDM2 抗体 (AA 1-347)

Cited in 2+ publications. The 小鼠 单克隆 anti-PRDM2 antibody (Clone 33AT1045) (ABIN387783) specifically detects PRDM2 in WB 和 ChIP. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN387783
发货至: 中国
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Quick Overview for PRDM2 抗体 (AA 1-347) (ABIN387783)

抗原

See all PRDM2 抗体
PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

适用

  • 63
  • 15
  • 12
人, 小鼠

宿主

  • 54
  • 10
小鼠

克隆类型

  • 55
  • 9
单克隆

标记

  • 15
  • 6
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This PRDM2 antibody is un-conjugated

应用范围

  • 34
  • 26
  • 26
  • 25
  • 13
  • 9
  • 8
  • 6
  • 2
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

克隆位点

33AT1045
  • 抗原表位

    • 15
    • 15
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-347

    纯化方法

    This antibody is purified through a protein G column, followed by dialysis against PBS.

    免疫原

    Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

    亚型

    IgG1
  • 应用备注

    CHIP: 1:100. CHIP: 1:100. CHIP: 1:100. WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression." in: Journal of hematology & oncology, Vol. 2, pp. 28, (2009) (PubMed).

    Carling, Kim, Yang, Gu, Zhang, Huang: "A histone methyltransferase is required for maximal response to female sex hormones." in: Molecular and cellular biology, Vol. 24, Issue 16, pp. 7032-42, (2004) (PubMed).

  • 抗原

    PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

    别名

    PRDM2 (RIZ1)

    背景

    This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

    分子量

    188915

    基因ID

    7799

    NCBI登录号

    NP_001007258, NP_001129082, NP_036363, NP_056950

    UniProt

    Q13029
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