Bone morphogenic protein 6. Pre-incubation of morph-6.1 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the antibody to tissue sections. Pre-incubation with other amino- terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as an irrelevant peptide does not inhibit specific tissue staining. Antigen distribution: Tissue sections: Positive staining can be observed in embryonic and adult central nervous system. Rat radial glial cells of the developing central nervous system from E11 to E19. In rat peripheral nerves a selective intracellular immunoreactivity can be found in perinuclear region of most Schwann cells which form the myelin sheath. However, some Schwann cells were negative for morph-6.1. BMP-6 can also be found in a variety of other tissues and cell types, notably keratinizing epithelial cells. Smooth muscle cells, characterized by Desmin positivity, were positively stained in normal tissues and in atherosclerotic plaques. Macrophages (CD68+) and endothelial cells were negative with morph-6.1. Specificity: Rat: Bone morphogenic Protein-6 (BMP-6) Synonyms are: vgr-1 (vegetal related) or DVR-6 (decapentaplegic vegetal related). Other species: phylogenetically highly conserved (human positive)
纯化方法
Affinity purified
免疫原
Aminoterminal synthetic peptide 1-29-KLh
Type of Immunogen: Synthetic peptide - KLH conjugated