HNF1B 抗体 (Internal Region)
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Quick Overview for HNF1B 抗体 (Internal Region) (ABIN375249)
抗原
See all HNF1B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- C-QAYDRQKNPS KEER
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特异性
- This antibody is expected to recognize both reported isoforms (NP_000449.1 and NP_001159395.1).
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Rat, Canine, Pig, Cow, Zebrafish.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide with sequence from the internal region of the protein according to NP_000449.1, NP_001159395.1. Genename: HNF1B
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应用备注
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Peptide ELISA: 1/64000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- HNF1B (HNF1 Homeobox B (HNF1B))
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别名
- HNF1 beta / TCF2
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背景
- TCF2 encodes transcription factor 2, a liver specific factor of the homeobox containing basic helix turn helix family. The TCF2 protein is believed to form heterodimers with another liver specific member of this transcription factor family, TCF1, depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. A mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat. However, to date such an mRNA species has not been isolated. TCF2 probably binds to the inverted palindrome 5' GTTAATNATTAAC 3'.Synonyms: HNF-1-beta, HNF-1B, Hepatocyte nuclear factor 1-beta, LFB3, TCF-2, Transcription factor 2, Variant hepatic nuclear factor 1, vHNF1
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基因ID
- 6928
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NCBI登录号
- NP_000449
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UniProt
- P35680
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途径
- Hormone Transport, Stem Cell Maintenance, Tube Formation
抗原
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