CCKAR 抗体 (Internal Region)
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Quick Overview for CCKAR 抗体 (Internal Region) (ABIN374792)
抗原
See all CCKAR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- C-KFDASQKKSA KEKR
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特异性
- This antibody detects CCK-A Receptor.
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交叉反应 （详细）
- Species reactivity (expected):Mouse, RabbitSpecies reactivity (tested):Rat.
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纯化方法
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
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免疫原
- Peptide from the internal region of the protein sequence according to NP_033957.1. Genename: Cckar
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anti-Cholecystokinin A Receptor (CCKAR) (Internal Region) antibody
Verified CCKAR 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (Internal Region) antibodyCCKAR 适用: 人, 犬, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (AA 235-313) antibodyCCKAR 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (AA 325-356), (C-Term) antibodyCCKAR 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (AA 228-257) antibodyCCKAR 适用: 人 WB 宿主: 兔 Polyclonal RB40248 unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (AA 161-200) antibodyCCKAR 适用: 人, 大鼠, 小鼠, 小鸡 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (AA 191-204) antibodyCCKAR 适用: 人 WB 宿主: 兔 unconjugated
anti-Cholecystokinin A Receptor (CCKAR) (AA 206-219) antibodyCCKAR 适用: 人 WB, IHC 宿主: 兔 unconjugated
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应用备注
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Peptide ELISA: antibody detection limit dilution 1: 64000. Western blot: 0.1-0.3 μg/mL. Approx.75 kDa band observed in purified membranes of Ratinsulinoma cell line RIN14B (calculated MW of 48.5 kDa according to NP_033957.1). Datakindly provided by Dr. Morisset, Sherbrooke, Canada. Data accepted by InternationalJournal of Endocrinology (in press). The observed molecular weight also corresponds toearlier findings in literature with different antibodies (Morisset et al J Histochem Cytochem.2003 Nov,51(11): 1501-13, PMID: 14566022).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide, with 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CCKAR (Cholecystokinin A Receptor (CCKAR))
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别名
- CCK-A Receptor
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背景
- The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.Synonyms: CCKA Receptor, CCKAR, CCKRA, Cholecystokinin receptor type A, Cholecystokinin-1 receptor
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基因ID
- 886, 9606
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UniProt
- P32238
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途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Feeding Behaviour
抗原
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