KPNA4 抗体 (C-Term)
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Quick Overview for KPNA4 抗体 (C-Term) (ABIN374394)
抗原
See all KPNA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- C-NSSANVPTEG FQF
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特异性
- This antibody detects Importin subunit alpha-4 at C-term.
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交叉反应 （详细）
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Species reactivity (expected):Rat, Canine (Dog), Cow.
Species reactivity (tested):Human, Mouse. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
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免疫原
- Peptide from C Terminus of the protein sequence according to NP_002259.1 Genename: KPNA4
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anti-Karyopherin (Importin) alpha 4 (KPNA4) (AA 1-240) antibody
KPNA4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (C-Term) antibodyVerified KPNA4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (AA 51-239) antibodyKPNA4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (N-Term) antibodyKPNA4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) antibodyKPNA4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (C-Term) antibodyKPNA4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (full length) antibodyKPNA4 适用: 小鼠 WB, ELISA 宿主: 大鼠 Monoclonal 3D10 unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (AA 1-100) antibodyKPNA4 适用: 小鼠 WB, ELISA, IF (p), IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (AA 471-521) antibodyKPNA4 适用: 人, 小鼠, Cow, 犬, 马, 兔, 豚鼠 IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin (Importin) alpha 4 (KPNA4) (AA 38-87) antibodyKPNA4 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.2-1 μg/mL. Approx 55-60 kDa band observed in Human Testis and Ovarylysates (predicted size of approx.50 kDa according to NP_002259.1). Immunohistochemistry: In paraffin embedded Human Testis, shows strong nuclearstaining of some cells in the seminiferous tubules (3 μg/mL). In paraffin embedded HumanSmall Intestine shows pixulate staining in nuclei of enterocytes (1-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))
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别名
- KPNA4 / Importin alpha-4
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背景
- KPNA4 (karyopherin alpha 4), also known as importin alpha 3, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.Synonyms: Importin alpha Q1, Karyopherin subunit alpha-4, QIP1
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基因ID
- 3840
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NCBI登录号
- NP_002259
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UniProt
- O00629
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途径
- Protein targeting to Nucleus
抗原
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