Peptide ELISA: Limit dilution 1: 1000. Western blot: 0.3-1 μg/mL. Approx 80 kDa band observed in human heart lysates(calculated MW of 81.0 kDa according to NP_114121.1). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity.Synonyms: C13orf4, Chronic lymphocytic leukemia deletion region gene 8 protein, Histone-lysine N-methyltransferase SETDB2, KMT1F, Lysine N-methyltransferase 1F, SET domain bifurcated 2