DBNL 抗体 (N-Term)
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Quick Overview for DBNL 抗体 (N-Term) (ABIN374214)
抗原
See all DBNL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- AANLSRNGPA LQE-C
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特异性
- This antibody is expected to recognise all reported isoforms (NP_054782.2, NP_001014436.1, NP_001116428.1).
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交叉反应 （详细）
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Species reactivity (expected):Rat, Canine (Dog).
Species reactivity (tested):Human, Mouse. -
纯化方法
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide from N Terminus of the protein sequence according to NP_054782.2, NP_001014436.1, NP_001116428.1. Genename: DBNL
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anti-Drebrin-Like (DBNL) (N-Term) antibody
DBNL 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Drebrin-Like (DBNL) (N-Term) antibodyVerified DBNL 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Drebrin-Like (DBNL) (AA 201-300) antibodyDBNL 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Drebrin-Like (DBNL) (AA 251-300) antibodyDBNL 适用: 人, 小鼠, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Drebrin-Like (DBNL) (AA 131-430) antibodyDBNL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Peptide ELISA: Limit dilution 1: 32000. Western blot: 1-3 μg/mL. Approx 55 kDa band observed in Jurkat and 3T3 lysates (predictedMW of 45 kDa according to NP_054782).
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- DBNL (Drebrin-Like (DBNL))
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别名
- Drebrin-Like Protein (DBNL)
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背景
- Cellular morphology, adhesion, and motility occur through dynamic reorganization of actin-based superstructures. Actin-binding proteins are critical for regulating actin polymerization and superstructure formation. The Arp2/3 complex is an actin polymerization-inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. Several actin binding proteins, WASP, cortactin, and Abp1, regulate the activity of the Arp2/3 complex. HIP55 is the mammalian homologue of the yeast HIP55, which has been shown to bind actin and to have roles in endocytosis. HIP55 contains a C-terminal Src homology 3 domain and an N-terminal actin depolymerization factor (ADF-H/C) domain that is homologous to a similar domain found in the actin severing protein, cofilin. HIP55 can bind Src kinases, hematopoietic progenitor kinase 1 (HPK-1), myosin I heavy chain kinase, and dynamin. Thus, HIP55 may be important for regulation of the actin cytoskeleton through its ability to interact with F-actin and various other cytoskeletal and cell signaling proteins. There are three different isoforms.Synonyms: CMAP, Cervical mucin-associated protein, Drebrin-F, HIP-55, HPK1-interacting protein of 55 kDa, SH3 domain-containing protein 7, SH3P7
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分子量
- 49kDa (NP_054782).
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基因ID
- 28988
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NCBI登录号
- NP_054782
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UniProt
- Q9UJU6
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途径
- TCR Signaling, Regulation of Actin Filament Polymerization
抗原
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