ALS2 抗体 (C-Term)
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Quick Overview for ALS2 抗体 (C-Term) (ABIN374168)
抗原
See all ALS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- LKACYYQIQR EKLN
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特异性
- This antibody detects Alsin / ALS2 at C-term.
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纯化方法
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
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免疫原
- Peptide from C Terminus of the protein sequence according to NP_065970.2 Genename: ALS2
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anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1-280) antibody
ALS2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 221-320) antibodyALS2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4F10 unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1-280) antibodyALS2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1248-1277), (C-Term) antibodyALS2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB18853 unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1007-1056) antibodyALS2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Bat, 猴, 豚鼠, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1-1237) antibodyALS2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1-1237) antibodyALS2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (C-Term) antibodyVerified ALS2 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (N-Term) antibodyALS2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (AA 1250-1300) antibodyALS2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Peptide ELISA: Limit dilution 1: 8000. Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Cortex shows pixulatecytoplasm staining in some neuronal cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
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- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
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别名
- Alsin / ALS2
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背景
- ALS2 specifically binds to, and functions as a guanine nucleotide exchange factor (GEF) for the small GTPase RAB5. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Loss of ALS2 function might underlie neuronal dysfunction and degeneration in a number of motor neuron diseases.Synonyms: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563
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基因ID
- 57679
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NCBI登录号
- NP_065970
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UniProt
- Q96Q42
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途径
- Skeletal Muscle Fiber Development
抗原
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