DRAM 抗体 (C-Term)
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Quick Overview for DRAM 抗体 (C-Term) (ABIN372924)
抗原
See all DRAM (DRAM1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody recognizes Damage-regulated Autophagy Modulator (DRAM).
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide - KLH conjugated corresponding to a 16 amino acids peptide from near the carboxy terminus of Human DRAM.
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亚型
- IgG
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anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) (AA 50-100) antibody
DRAM1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) (AA 70-119) antibodyDRAM1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) (N-Term) antibodyDRAM1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) (N-Term) antibodyDRAM1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA. Western blot: 0.5-1.0 μg/mL. Immunohistochemistry on Frozen Sections: 2.5 μg/mL. Immunohistochemistry on Paraffin Sections: 3 μg/mL. This antibody was validated for use in immunohistochemistry on a panel of 21formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody LS-D1, followed by alkalinephosphatase-streptavidin and chromogen.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
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别名
- DRAM1
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背景
- Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.Synonyms: DNA damage regulated autophagy modulator protein 1, DRAM, DRAM-1, FLJ11259
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基因ID
- 55332
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NCBI登录号
- NP_060840
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UniProt
- Q8N682
抗原
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