Cathepsin K 抗体
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北京 101111
Quick Overview for Cathepsin K 抗体 (ABIN372829)
抗原
See all Cathepsin K (CTSK) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The antibody detects proform (43 kDa) and the mature form (29 kDa) of Cathepsin K.
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交叉反应 （详细）
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Species reactivity (expected):Chicken, Human, Mouse, Porcine, Rabbit.
Species reactivity (tested):Rat. -
纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Synthetic peptide surrounding amino acid 321 of Rat Cathepsin K .
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亚型
- IgG
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anti-Cathepsin K (CTSK) (AA 54-317) antibody
CTSK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 163-274) antibodyCTSK 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CTSK-2791 unconjugated
anti-Cathepsin K (CTSK) (AA 220-329) antibodyCTSK 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Cathepsin K (CTSK) (AA 115-329) antibodyCTSK 适用: 人 WB 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Cathepsin K (CTSK) (AA 71-319) antibodyCTSK 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 115-329) antibodyCTSK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 220-331) antibodyCTSK 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Cathepsin K (CTSK) (AA 115-329) antibodyCTSK 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (N-Term) antibodyCTSK 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 97-126) antibodyCTSK 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19253 unconjugated
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应用备注
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Western blot: 0.5-4 μg/mL. Immunoprecipitation. Immunohistochemistry on Paraffin Sections: 2.5 μg/mL. This antibody was validated for use in immunohistochemistry on a panel of 21formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody, followed by alkalinephosphatase-streptavidin and chromogen.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2, 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Cathepsin K (CTSK)
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别名
- Cathepsin K
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背景
- Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin K expression is highest in bone, cartilage, and skeletal muscle. Cathepson K is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in the gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.Synonyms: CTSK, CTSO, CTSO2, Cathepsin O, Cathepsin O2, Cathepsin X
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基因ID
- 1513
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NCBI登录号
- NP_000387
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UniProt
- P43235
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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