PNPLA2 抗体 (Internal Region)
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Quick Overview for PNPLA2 抗体 (Internal Region) (ABIN372772)
抗原
See all PNPLA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- Recognizes Patatin-Like Phospholipase Domain Containing 2 (PNPLA2).
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交叉反应 (详细)
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Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse. -
纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide (C-NIIEVSKEARKR) from an internal region of Mouse PNPLA2.
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亚型
- IgG
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应用备注
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ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))
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别名
- PNPLA2 / ATGL
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背景
- Adipose triglyceride lipase (ATGL) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. ATGL catalyzes the initial step in triglyceride hydrolysis in mammalian adipose tissue. ATGL contains a patatin domain common to plant acyl hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammalsSynonyms: Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, FP17548, IPLA2-zeta, Patatin-like phospholipase domain-containing protein 2, Pigment epithelium-derived factor, TTS2.2, Transport-secretion protein 2
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基因ID
- 57104
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NCBI登录号
- NP_065109
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UniProt
- Q96AD5
抗原
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