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GRIN2B 抗体 (C-Term)

Name: GRIN2B 抗体 (C-Term)
SKU: ABIN372682
Availability: OutOfStock

GRIN2B 适用: 人, 大鼠, 小鼠 WB, IP, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Image no. 1 for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (C-Term) antibody (ABIN372682) (GRIN2B 抗体 (C-Term))

1 image

(8 references)

产品编号 ABIN372682

发货至: 中国

Datasheet as PDF

抗原 See all GRIN2B 抗体

GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
抗原表位
32

29

22

21

21

20

16

10

9

7

5

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
187

171

145

27

24

21

10

7

5

5

3

2

2

2

2

2

2

1

1
人, 大鼠, 小鼠
宿主
197

35

1
兔
Compatible Secondaries
克隆类型
199

34
多克隆
标记
97

11

9

9

9

9

9

9

7

7

6

5

5

5

5

5

3

3

3

3

2

2

2

2

2

2

2
This GRIN2B antibody is un-conjugated
应用范围
191

65

65

64

46

39

24

24

23

18

15

10

10

2

2

2

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

特异性

This antibody recognizes the ~180k NR2B subunit of the NMDA receptor. No reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.

交叉反应（详细）

Species reactivity (tested):Human, Mouse and Rat.

纯化方法

Affinity Chromatography.

免疫原

Fusion protein from the C-terminus of the NR2B subunit of rat NMDA Receptor.

亚型

IgG

Top Product

Discover our top product GRIN2B Primary Antibody
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (HRP)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 HRP

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (FITC)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 FITC

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Biotin)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Biotin

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (PE)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 PE

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (APC)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 APC

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (PerCP)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 PerCP

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 488)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Atto 488

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 594)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Atto 594

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 20-271) antibody (Atto 390)
GRIN2B 适用: 大鼠 WB, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal S59 Atto 390

anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 27-163) antibody
GRIN2B 适用: 人 WB, IHC, ELISA, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 6E9A8 unconjugated

应用备注

Western blot: 1/1000. Immunoprecipitation: 3 μL per 200 μg lysate. Immunohistochemistry: 1/1000-1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
溶解方式

Restore in 50 μL PBS (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.

缓冲液

5 mM Ammonium Bicarbonate.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store the antibody undiluted (in aliquots) at-20 °C.
Hayano, Takasu, Koyama, Yamada, Ogawa, Minami, Asaki, Kitada, Kuwabara, Yamashita: "Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B." in: The Journal of experimental medicine, Vol. 213, Issue 13, pp. 2949-2966, (2017) (PubMed).

Kucharova, Stallcup: "NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair." in: Journal of neuroinflammation, Vol. 12, pp. 161, (2016) (PubMed).

Brady, Diaz, Iuso, Everett, Valenzuela, Caldwell: "Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 3, pp. 1062-7, (2013) (PubMed).

Hicklin, Wu, Radcliffe, Freund, Goebel-Goody, Correa, Proctor, Lombroso, Browning: "Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 16, pp. 6650-5, (2011) (PubMed).

Kurup, Zhang, Xu, Venkitaramani, Haroutunian, Greengard, Nairn, Lombroso: "Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 17, pp. 5948-57, (2010) (PubMed).

Xu, Kurup, Zhang, Goebel-Goody, Wu, Hawasli, Baum, Bibb, Lombroso: "Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 29, pp. 9330-43, (2009) (PubMed).

Davies, Goebel-Goody, Coultrap, Browning: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).

Chernova, Steinert, Guerin, Nicotera, Forsythe, Smith: "Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 32, pp. 8475-85, (2007) (PubMed).
抗原

GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

别名

NMDAR2B (GRIN2B 产品)

别名

NMDAR2B antibody, GluN2B antibody, MRD6 antibody, NR2B antibody, hNR3 antibody, nmdar2b antibody, nr2b antibody, AW490526 antibody, Nmdar2b antibody, glutamate ionotropic receptor NMDA type subunit 2B antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog antibody, glutamate receptor, ionotropic, NMDA2B (epsilon 2) antibody, GRIN2B antibody, Grin2b antibody, grin2b.L antibody

背景

The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be clonedand it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a, Clayton et al., 2002b). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999).Synonyms: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B

基因ID

2904

NCBI登录号

NP_000825

UniProt

Q13224

途径

Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity