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STXBP1 抗体 (pSer515)

The 兔 多克隆 anti-STXBP1 antibody is suitable to detect STXBP1 in samples from 人, 小鼠, 大鼠, Cow, 犬, 小鸡 和 非洲爪蟾. It has been validated for WB 和 IHC (fro).
产品编号 ABIN372671
发货至: 中国
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Quick Overview for STXBP1 抗体 (pSer515) (ABIN372671)

抗原

See all STXBP1 抗体
STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

适用

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人, 小鼠, 大鼠, Cow, 犬, 小鸡, 非洲爪蟾

宿主

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克隆类型

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多克隆

标记

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This STXBP1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    pSer515

    特异性

    This antibody recognizes ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.

    纯化方法

    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

    免疫原

    Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser515 of Munc-18.

    亚型

    IgG
  • 应用备注

    Western blot: 1/1000. Immunohistochemistry: 1/400. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody undiluted (in aliquots) at-20°C.

    有效期

    12 months
  • 抗原

    STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

    别名

    STXBP1 / UNC18A

    背景

    Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996).
    Alternate names: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

    基因ID

    25558

    NCBI登录号

    NP_037170

    UniProt

    P61765

    途径

    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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