GRM1a / GRM5 抗体 (C-Term)
This 兔 多克隆 antibody specifically detects GRM1a / GRM5 in WB 和 IHC (fro). It exhibits reactivity toward 大鼠, 人 和 小鼠.
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产品编号 ABIN372670
发货至:
中国
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Quick Overview for GRM1a / GRM5 抗体 (C-Term) (ABIN372670)
抗原
GRM1a / GRM5 (GRM5/1a)
(Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))
适用
大鼠, 人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This GRM1a / GRM5 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
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抗原表位
- C-Term
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交叉反应 （详细）
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Species reactivity (expected):Human and Mouse.
Species reactivity (tested):Rat. -
纯化方法
- Affinity Chromatography.
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免疫原
- Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 5/1a (GRM5/1a) (C-Term) antibody
GRM5/1a 适用: 大鼠, 人, 小鼠 WB, IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))
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别名
- mGluR5/1a
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背景
- The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).Synonyms: GRM1A, GRM5, MGLUR1a, MGLUR5, Metabotropic Glutamate Receptor 5/1a
抗原
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