GAP43 抗体 (pSer41)
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- 抗原 See all GAP43 抗体
- GAP43 (Growth Associated Protein 43 (GAP43))
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抗原表位
- pSer41
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适用
- 人, 大鼠, 小鼠, 小鸡, Cow, 斑马鱼, 犬, 非洲爪蟾, Finch, Non-Human Primate
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GAP43 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- Specific for the ~50k Gap-43 protein phosphorylated at Ser41 in Western Blots of Rat brain lysate. In some tissues the antibody also recognizes a higher molecular weight protein that is also recognized by the pan Gap-43 antibody, that may be a Gap-43 aggregate or oligomer. Immunolableing is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is completely eliminated by treatment with lambda-Ptase.
- 交叉反应 （详细）
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Species reactivity (expected):Bovine, Canine, Chicken, Finch, Human, Mouse, non-Human Primates, Xenopus and Zebrafish.
Species reactivity (tested):Rat. - 纯化方法
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
- 免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser41 of Gap-43.
- 亚型
- IgG
- Top Product
- Discover our top product GAP43 Primary Antibody
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anti-Growth Associated Protein 43 (GAP43) (AA 9-100) antibody
GAP43 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) (AA 1-274) antibodyGAP43 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) antibodyGAP43 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) (AA 1-238) antibodyGAP43 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) (AA 1-238) antibodyGAP43 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Growth Associated Protein 43 (GAP43) (C-Term) antibodyGAP43 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) (AA 1-238) antibodyGAP43 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) antibodyGAP43 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) antibodyGAP43 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Growth Associated Protein 43 (GAP43) (AA 8-226) antibodyGAP43 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blot: 1/1000. Immunohistochemitsry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- 抗原
- GAP43 (Growth Associated Protein 43 (GAP43))
- 别名
- GAP43 (GAP43 产品)
- 别名
- B-50 antibody, PP46 antibody, Basp2 antibody, GAP-43 antibody, b-50 antibody, gap-43 antibody, gap43b antibody, pp46 antibody, cb310 antibody, gap antibody, gap43 antibody, gap43a antibody, growth associated protein 43 antibody, growth associated protein 43 L homeolog antibody, growth associated protein 43 S homeolog antibody, GAP43 antibody, Gap43 antibody, gap43.L antibody, gap43 antibody, gap43.S antibody
- 背景
- Gap-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C (Catalog No. 1609-PKC) modulates the interaction of Gap-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).Synonyms: Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, PP46
- 基因ID
- 29423
- NCBI登录号
- NP_058891
- UniProt
- P07936
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