GABBR1 抗体 (pSer923)
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Quick Overview for GABBR1 抗体 (pSer923) (ABIN372645)
抗原
See all GABBR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer923
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特异性
- Specific for ~102k GABAB R1 phosphorylated at Ser923. Immunolabeling of the GABAB R1 band is completely blocked by lambda-phosphatase treatment.
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交叉反应 (详细)
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Species reactivity (expected):Human, Bovine, Mouse and non-Human Primates.
Species reactivity (tested):Rat. -
纯化方法
- Sequential Chromatography on phospho- and dephospho-peptide affinity columns.
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免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1
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亚型
- IgG
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应用备注
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
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别名
- GABBR1
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背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.Synonyms: GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, GPRC3A, Gamma-aminobutyric acid type B receptor subunit 1, Gb1
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基因ID
- 81657
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NCBI登录号
- NP_112290
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UniProt
- Q9Z0U4
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途径
- Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process
抗原
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