GABRG2 抗体 (pSer327)
Quick Overview for GABRG2 抗体 (pSer327) (ABIN372642)
抗原
See all GABRG2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer327
-
特异性
- Specific for ~45k GABAA Receptor Gamma2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by Lambda-phosphatase treatment.
-
交叉反应 （详细）
-
Species reactivity (expected):Human, Bovine, Canine, Chicken, Mouse and non-Human Primates.
Species reactivity (tested):Rat. -
纯化方法
- Sequential Chromatography on phospho- and dephospho-peptide affinity columns.
-
免疫原
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser327 of the GABAA Receptor, Gamma2 subunit.
-
亚型
- IgG
-
-
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (pSer327) antibody
GABRG2 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 41-140) antibodyGABRG2 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (N-Term) antibodyGABRG2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 170-270) antibodyGABRG2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 198-224) antibodyGABRG2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB23939 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) antibodyGABRG2 适用: 人, 小鼠, 大鼠 IP, ICC 宿主: 小鼠 Monoclonal 331A12 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 198-224) antibodyGABRG2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 42-108) antibodyGABRG2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (AA 61-110) antibodyGABRG2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, Pig, 马, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) (N-Term) antibodyVerified GABRG2 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
-
-
应用备注
-
Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
-
-
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
-
别名
- GABRG2
-
背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKC-epsilon regulates the sensitivity of GABAA Alpha1/Beta2/Gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of Gamma2 (Qi et al., 2007)Synonyms: GABA A Receptor subunit gamma-2, GABRG-2, Gamma-aminobutyric acid receptor subunit gamma-2
-
基因ID
- 29709
-
NCBI登录号
- NP_899156
-
UniProt
- P18508
抗原
-
