GABRA1 抗体 (N-Term)
Quick Overview for GABRA1 抗体 (N-Term) (ABIN372627)
抗原
See all GABRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- Specific for the ~51k Alpha-1 subunit of the GABAA receptor in Western blots of rat brain. Labeling is absent in Alpha-1 subunit knockout animals.
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交叉反应 （详细）
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Species reactivity (expected):Human, Bovine, Canine and non-Human Primates.
Species reactivity (tested):Rat and Mouse. -
纯化方法
- Affinity Chromatography.
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免疫原
- Peptide from the N-terminal region of the Alpha-1 subunit of rat GABAA Receptor, conjugated to keyhole limpet hemocyanin (KLH).
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亚型
- IgG
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anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody
GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibodyGABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (HRP)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) HRP
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (HRP)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 HRP
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (FITC)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) FITC
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (FITC)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 FITC
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (Biotin)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) Biotin
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (Biotin)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 Biotin
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 15-34) antibody (PE)GABRA1 适用: 大鼠 WB, ICC, IF, AA 宿主: 小鼠 Monoclonal N151-3 (Formerly S151-3) PE
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) (AA 350-385) antibody (PE)GABRA1 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S399-19 PE
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应用备注
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))
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别名
- GABRA1
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背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABA A receptor subunit alpha-1, GABRA-1, Gamma-aminobutyric acid receptor subunit alpha-1
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基因ID
- 14394
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NCBI登录号
- NP_034380
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UniProt
- P62812
抗原
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