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SNCA 抗体 (pSer129)

SNCA 适用: 人, 大鼠, 小鼠, Cow, 犬, Non-Human Primate WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN372588
发货至: 中国
  • 抗原 See all SNCA 抗体
    SNCA (Synuclein, alpha (SNCA))
    抗原表位
    • 72
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    pSer129
    适用
    • 291
    • 198
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    • 13
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    • 5
    • 2
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    人, 大鼠, 小鼠, Cow, 犬, Non-Human Primate
    宿主
    • 237
    • 97
    • 4
    • 1
    • 1
    • 1
    克隆类型
    • 222
    • 120
    多克隆
    标记
    • 143
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    This SNCA antibody is un-conjugated
    应用范围
    • 237
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    Western Blotting (WB)
    特异性
    Recognizes the ~15 kDa alpha-Synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
    交叉反应 (详细)
    Species reactivity (expected):Bovine, Canine, Human, Mouse and non-Human Primates.
    Species reactivity (tested):Rat.
    纯化方法
    Affinity Chromatography.
    免疫原
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha Synuclein.
    亚型
    IgG
    Top Product
    Discover our top product SNCA Primary Antibody
  • 应用备注
    Western Blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted (in aliquots) at-20 °C.
  • 抗原
    SNCA (Synuclein, alpha (SNCA))
    别名
    alpha-Synuclein / SNCA (SNCA 产品)
    别名
    snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
    背景
    Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005, Masliah et al., 2005).Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
    基因ID
    29219
    NCBI登录号
    NP_062042
    UniProt
    P37377
    途径
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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