HAVCR1 抗体 (AA 200-300)
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Quick Overview for HAVCR1 抗体 (AA 200-300) (ABIN372415)
抗原
See all HAVCR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 200-300
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特异性
- This antibody recognizes Hepatitis A Virus Cellular Receptor 1 (HAVCR1).
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交叉反应 (详细)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
纯化方法
- Protein G Chromatography.
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免疫原
- Synthetic peptide corresponding amino acids 200-300 of human HAVCR1.
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亚型
- IgG
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应用备注
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Immunohistochemistry on Paraffin Sections: 2.5-5.0 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA as stabilizer and 0.05 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
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别名
- TIMD1 / HAVCR1
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物质类
- Virus
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背景
- HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.Synonyms: HAVCR-1, Hepatitis A virus cellular receptor 1, T cell immunoglobulin and mucin domain-containing protein 1, T cell membrane protein 1, TIM-1, TIM1, TIMD-1
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基因ID
- 26762
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NCBI登录号
- NP_001092884
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UniProt
- Q96D42
抗原
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