Acetylcholinesterase 抗体 (N-Term)
Quick Overview for Acetylcholinesterase 抗体 (N-Term) (ABIN372290)
抗原
See all Acetylcholinesterase (AChE) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody recognizes Acetylcholinesterase (ACHE).
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交叉反应 (详细)
- Species reactivity (tested):Human.
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纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide corresponding to N-terminal residues of Human Acetylcholinesterase (N- terminal extended acetylcholinesterase).
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亚型
- IgG
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应用备注
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Immunohistochemistry on Paraffin Sections: 20 μg/mL. Western Blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.01 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Acetylcholinesterase (AChE)
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别名
- Acetylcholinesterase
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背景
- Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.Synonyms: AChE, Acetylcholine Esterase, Acetylcholine-Esterase
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分子量
- 68 kDa.
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基因ID
- 43
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NCBI登录号
- NP_000656
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UniProt
- P22303
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途径
- Skeletal Muscle Fiber Development
抗原
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