THRA 抗体 (N-Term)
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Quick Overview for THRA 抗体 (N-Term) (ABIN371843)
抗原
See all THRA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- N-Term
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特异性
- AM08268PU-N is specific for the ~50k THR alpha-1 and the ~58k THR alpha-2 proteins.
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交叉反应 (详细)
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Species reactivity (expected):Canine (Dog), Mouse and Rat.
Species reactivity (tested):Human. -
产品特性
- Synonyms: Thyroid hormone receptor alpha, THRA1, THRA2, C-erbA-alpha, c-erbA-1, EAR-7, EAR7,NR1A1, Nuclear receptor subfamily 1 group A member 1
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纯化方法
- Prepared from Mouse Ascites by Ammonium Sulfate Precipitation followed by Affinity Chromatography on Protein G.
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免疫原
- Peptide corresponding to amino acid residues from the N-terminal region of human thyroidhormone receptor, alpha1/alpha2-isotype.
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亚型
- IgG1
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应用备注
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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储存条件
- -20 °C
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储存方法
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Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- THRA (Thyroid Hormone Receptor, alpha (THRA))
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别名
- THRA / ERBA1
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背景
- Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR-alpha1, TR-alpha2, TR-beta1 and TR-beta2. TR-alpha1, TR-beta1 and TR-beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1
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基因ID
- 7067
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UniProt
- P10827
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development
抗原
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