MMP1 抗体
Quick Overview for MMP1 抗体 (ABIN371653)
抗原
See all MMP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody is specific for Human MMP-1. Does not cross react with Human MMP-2, MMP-3 or MMP-9. Other species not tested.
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产品特性
- Synonyms: Interstitial collagenase, Matrix metalloproteinase-1, Fibroblast collagenase, MMP1, CLG
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纯化方法
- Purified
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免疫原
- Recombinant MMP-1.
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亚型
- IgG2b
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anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibody
MMP1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 1-469) antibodyMMP1 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibodyMMP1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6A5 unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 169-464) antibodyMMP1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 20-280) antibodyMMP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (N-Term) antibodyMMP1 适用: 人, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 1-469) antibodyMMP1 适用: 人 WB, IHC (p), PLA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (C-Term) antibodyMMP1 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 317-347) antibodyMMP1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (C-Term) antibodyMMP1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/3,000-1/8,000. Western Blot. Immunohistochemistry (Frozen/Paraffin): < / = 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))
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别名
- MMP-1
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背景
- The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP1, also known as interstitial collagenase, is the only enzyme that is able to initiate the breakdown of the interstitial collagens, types I, II, and IIISynonyms: CLG, Fibroblast collagenase, Interstitial collagenase, MMP1, Matrix metalloproteinase-1
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UniProt
- P03956
抗原
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